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The concomitant administration of the protease inhibitor ritonavir significantly will increase serum concentrations of sildenafil (11-fold boost in AUC). If VIAGRA is prescribed to people getting ritonavir, warning should be employed. Facts from topics exposed fake kamagra to higher systemic levels of sildenafil are restricted.

The mean constant point out quantity of distribution (Vss) fake cialis for sildenafil is 105 L, indicating distribution into your tissues. Sildenafil and its major circulating N-desmethyl metabolite are equally approximately 96% sure to plasma proteins. Protein binding is independent of overall drug concentrations.

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